Yes, the hub is identical
Same 5x112 PCD and same 57.1 mm centre bore: wheels from Audi RS3 bolt on and centre on Audi S8 4E without rings. You still need to check the offset and tyres, detailed below.
≈: width estimated from the original tyre size.
Wheel by wheel: offset and tyres
Each original wheel from Audi RS3 is compared with the one from Audi S8 4E of the same diameter: how much closer the wheel gets to the shock absorber or how far it sticks out of the wheel arch, and whether the tyre keeps the same overall diameter.
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8Jx18 ET50 · 225/40R18 — Check on the car
Compared with the original ≈8Jx18 ET40 on Audi S8 4E: shock absorber side +10 mm, wheel arch side −10 mm, tyre diameter −7.2 % : fit it with the original tyre size of Audi S8 4E (255/45R18), not that of Audi RS3.
Comparison for guidance only (estimated width). Check in detail
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8Jx19 ET50 · 235/35R19
Audi S8 4E has no 19-inch original wheel in our data: check the approved fitments and caliper clearance.
Before fitting the wheels
An identical hub is not enough: offset, width and diameter change the position of the wheel, and larger calipers can touch a smaller wheel. Original wheels often use bolts or nuts with a specific seat: keep the fixings intended for the wheel, with the thread of Audi S8 4E (M14x1.50), tightened to the torque shown on its vehicle page. Finally, check that the size is among the approved fitments for your vehicle. This comparison is for guidance only: have the fitting approved by a professional.
And the other way round: wheels from Audi S8 4E on Audi RS3?