Wheels from Cadillac XT5 on GMC Acadia: compatible?

No, the centre bore is too small

Same 6x120 PCD, but the centre bore of the wheels from Cadillac XT5 (66.9 mm) is smaller than the hub of GMC Acadia (74.5 mm): they will not fit without being re-bored by a professional.

Cadillac XT5from 2017GMC Acadia2006–2016
PCD6x1206x132 / 6x120
Centre bore66.9 mm74.5 mm
ThreadEcrous - 14x1.50Ecrous - 14x1.50
Original wheels ≈7.5Jx18 ET50 ≈7.5Jx17 ET50
≈8Jx18 ET50

≈: width estimated from the original tyre size.

Before fitting the wheels

An identical hub is not enough: offset, width and diameter change the position of the wheel, and larger calipers can touch a smaller wheel. Original wheels often use bolts or nuts with a specific seat: keep the fixings intended for the wheel, with the thread of GMC Acadia (Ecrous - 14x1.50), tightened to the torque shown on its vehicle page. Finally, check that the size is among the approved fitments for your vehicle. This comparison is for guidance only: have the fitting approved by a professional.

And the other way round: wheels from GMC Acadia on Cadillac XT5?

Other wheels that fit GMC Acadia