Yes, the hub is identical
Same 5x114.3 PCD and same 60.1 mm centre bore: wheels from Lexus RX bolt on and centre on Lexus GS450h without rings. You still need to check the offset and tyres, detailed below.
≈: width estimated from the original tyre size.
Wheel by wheel: offset and tyres
Each original wheel from Lexus RX is compared with the one from Lexus GS450h of the same diameter: how much closer the wheel gets to the shock absorber or how far it sticks out of the wheel arch, and whether the tyre keeps the same overall diameter.
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≈7.5Jx18 ET30 · 235/65R18 — Check on the car
Compared with the original ≈7.5Jx18 ET45 on Lexus GS450h: shock absorber side −15 mm, wheel arch side +15 mm, tyre diameter +16.8 % : fit it with the original tyre size of Lexus GS450h (245/40R18), not that of Lexus RX.
Comparison for guidance only (estimated width). Check in detail
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≈7.5Jx19 ET40 · 235/60R19
Lexus GS450h has no 19-inch original wheel in our data: check the approved fitments and caliper clearance.
Before fitting the wheels
An identical hub is not enough: offset, width and diameter change the position of the wheel, and larger calipers can touch a smaller wheel. Original wheels often use bolts or nuts with a specific seat: keep the fixings intended for the wheel, with the thread of Lexus GS450h (Ecrous - 12x1.50), tightened to the torque shown on its vehicle page. Finally, check that the size is among the approved fitments for your vehicle. This comparison is for guidance only: have the fitting approved by a professional.
And the other way round: wheels from Lexus GS450h on Lexus RX?