Yes, the hub is identical
Same 5x120 PCD and same 64.1 mm centre bore: wheels from Acura MDX bolt on and centre on Honda CR-V RS without rings. You still need to check the offset and tyres, detailed below.
≈: width estimated from the original tyre size.
Wheel by wheel: offset and tyres
Each original wheel from Acura MDX is compared with the one from Honda CR-V RS of the same diameter: how much closer the wheel gets to the shock absorber or how far it sticks out of the wheel arch, and whether the tyre keeps the same overall diameter.
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≈7.5Jx18 ET55 · 245/60R18 — Check on the car
Compared with the original 7.5Jx18 ET40 on Honda CR-V RS: shock absorber side +15 mm, wheel arch side −15 mm, tyre diameter +1.6 %.
Comparison for guidance only (estimated width). Check in detail
Before fitting the wheels
An identical hub is not enough: offset, width and diameter change the position of the wheel, and larger calipers can touch a smaller wheel. Original wheels often use bolts or nuts with a specific seat: keep the fixings intended for the wheel, with the thread of Honda CR-V RS (M14x1.5), tightened to the torque shown on its vehicle page. Finally, check that the size is among the approved fitments for your vehicle. This comparison is for guidance only: have the fitting approved by a professional.
And the other way round: wheels from Honda CR-V RS on Acura MDX?